SERENE is the Swiss Epilepsy Research Network, founded by the Swiss League Against Epilepsy in 2019. SERENE is open to all members of the Swiss Epilepsy League who conduct scien­tific research into epilepsy in Switzerland.

SERENE wants to streng­then epilepsy research in Switzer­land through colla­bo­ra­tion. One of its aims is to improve access to research-relevant data throu­ghout Switzer­land (in line with the provi­sions of data protec­tion and ethics commis­sions). Members present new research projects on meetings during major neuro­lo­gical conven­tions in Switzer­land, or online.

Benefits to SERENE members

  • Access to a broad network of Swiss epilepsy resear­chers that improves exchange and avoids redundancies
  • Help in finding partners for multi-centre projects and recrui­ting patients for studies
  • Provi­sion of advice and feedback concer­ning funding
  • Newsletter keeping members up to date

Current projects

Project (click to download PDF)
Insti­tu­tion / Contact
In search of IRB Status
Forecas­ting seizure risk over days using chronic EEG recordings e‑Lab Bern Univer­sity / UCSF - Approved Almost completed
Probing cortical excita­bi­lity in patients implanted with icEEG e‑Lab Bern Univer­sity / Inselspital Patients Approved Ongoing 2019–2022
Seizures-on-demand : Mouse model of seizures that are triggered using optogenetics e‑Lab Bern Univer­sity / Inselspital - Approved Ongoing 2019–2022
Minimally invasive chronic EEG : Clinical trial of sub-scalp device e‑Lab Bern Univer­sity / Insels­pital / Wyss Center Patients Pending Ongoing 2020–2022
Inter­ac­tions between spatio-temporal epileptic network and memory networks in humans EEG and Epilepsy Unit, HUG, Univer­sity of Geneva  Patients Pending Pilots
Markers of epileptic activity in simul­ta­neous scalp and intra­cra­nial EEG EEG and Epilepsy Unit, HUG, Univer­sity of Geneva  Partners Approved Ongoing
Source and network analyses of epileptic activity during wakeful­ness and sleep EEG and Epilepsy Unit, HUG, Univer­sity of Geneva  Partners Pending Starting
Trimodal charac­te­ri­za­tion of struc­tural and functional brain connec­ti­vity in focal epilepsy using concur­rent EEG-fMRI and tractography EEG and Epilepsy Unit, HUG, Univer­sity of Geneva  Patients, Partners Approved Ongoing
“PRESUDE” Brainstem MRI biomarker to PREdict the risk of Sudden Unexpected Death in Epilepsy Service de Neuro­logie, CHUV, Lausanne Partners Approved Ongoing
Inves­ti­ga­ting the effects of closed-loop auditory stimu­la­tion on sleep and behavior in children with sleep-dependent epilepsy Univer­sity Children’s Hospital Zurich Patients Approved Recruit­ment
Electro­phy­sio­lo­gical recor­ding of high frequency oscil­la­tions (HFO) to charac­te­rize epilep­to­genic brain tissue in patients Univer­sitätsS­pital Zürich, Klinik für Neurochirurgie Partners Approved Funded, ongoing
The connec­ti­vity and anatomy of the poste­rior hippo­campal commis­sure in Humans Univer­sitätss­pital Zürich, Klinik für Neurochirurgie - Approved Almost completed
Cogni­tive profile in elderly epileptic patients treated with peram­panel as first add-on Neuro­centro della Svizzera Italiana, Lugano  Partners Planned Appli­ca­tion for funding
CERTA “Conti­nuous EEG Rando­mized Trial in Adults” CHUV, Lausanne Partners Approved Data analyses ongoing
Thera­peutic drug monito­ring of newer genera­tion antiepi­leptic drugs CHUV, Lausanne (Partners) Approved Data collected, currently analy­sing data
Swiss First Insels­pital, Bern ; HUG, Geneva - Approved Ongoing
SEVERITY : Quanti­fying the severity of genera­lized tonic-clonic seizures (GTCS) with connected devices Service de Neuro­logie, CHUV, Lausanne Partners Approved Recruit­ment ongoing
Predic­tive models for starting antisei­zure medica­tion withdrawal follo­wing epilepsy surgery Univer­sitätss­pital Zürich, Neurologie Partners Approved Ongoing
High Frequency Oscil­la­tions in Pedia­tric Scalp EEG Reflect Epilep­to­ge­nesis and Treat­ment Response Univer­sity Children’s Hospital Zurich - Approved Ongoing
Scalp HFOs predict the develop­ment of epilepsy after neonatal seizures Univer­sity Children’s Hospital Zurich - Approved Ongoing
Model­ling changes in synaptic physio­logy in paedia­tric status epilepticus Univer­sity Children’s Hospital Zurich - Approved Ongoing
Detec­tion of focal cortical dyspla­sias in pedia­tric drug-resistant epilepsy Univer­sity Children’s Hospital Zurich - Approved Ongoing
Predic­tors of cogni­tive develop­ment after epilepsy surgery in the first years of life Univer­sity Children’s Hospital Zurich - Approved Ongoing
NORSE and longi­tu­dinal MRI (inclu­sion criteria) Univer­sitätss­pital Zürich, Neurologie Partners Ongoing

Parti­ci­pa­ting institutions

  • Neuro­lo­gische Univer­sitätsk­linik, Univer­sitätss­pital Basel
  • Universitäts-Kinderspital beider Basel UKBB
  • Univer­sität­sins­titut für Neuro­ra­dio­logie, Insels­pital, Bern
  • Schlaf-Wach-Epilepsie-Zentrum SWEZ, Univer­sitätsk­linik für Neuro­logie, Insels­pital, Bern
  • Unité d’épileptologie/EEG, Hôpitaux Univer­si­taires de Genève (HUG)
  • Unité de Neuro­pé­dia­trie, Hôpitaux Univer­si­taires de Genève (HUG)
  • Service de Neuro­logie, CHUV, Lausanne
  • Unité de Neuro­pé­dia­trie, CHUV, Lausanne
  • Insti­tu­tion de Lavigny
  • Neuro­centro della Svizzera Italiana, Ospedale Civico, Lugano
  • Service de Neuro­logie, Hôpital du Valais, Sion
  • Neuro­lo­gische Klinik, Kantonss­pital St. Gallen
  • Kinder­neu­ro­lo­gische Abtei­lung, Ostsch­weizer Kinders­pital, St.Gallen
  • Klinik Bethesda, Tschugg
  • Schwei­ze­rische Epilepsie-Klinik Klinik Lengg, Zürich
  • Universitäts-Kinderklinik, Zürich
  • Kliniken für Neuro­logie und Neuro­chi­rurgie, Univer­sitätss­pital Zürich

SERENE is open to further insti­tu­tions (research insti­tu­tions, other hospi­tals) as well as indivi­dual basic/translational scien­tists, neuro­psy­cho­lo­gists, nurses, social workers, physical, occupa­tional and speech thera­pists, etc. 

Advice concer­ning funding from foundations

Hints from Swiss­Foun­da­tions (D/F)

Special service to SERENE members : feedback on founda­tion applications

Last updated : March 2023